The authors at Cold Spring Harbor Laboratory functionally identify chromodomain helicase DNA binding domain 5 (Chd5) as a tumor suppressor that controls proliferation, apoptosis, and senescence via the p19Arf/p53 pathway. They demonstrate that Chd5 functions as a tumor suppressor in vivo and implicate deletion of CHD5 in human cancer.
Cell, Vol 128, 459-475, 09 February 2007
